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Compatibility of rev gene activity in the four groups of primate lentiviruses

Identifieur interne : 001505 ( Main/Exploration ); précédent : 001504; suivant : 001506

Compatibility of rev gene activity in the four groups of primate lentiviruses

Auteurs : Hiroyuki Sakai [Japon] ; Riri Shibata [Japon] ; Jun-Ichi Sakuragi [Japon] ; Takahiro Kiyomasu [Japon] ; Meiko Kawamura [Japon] ; Masanori Hayami [Japon] ; Akinori Ishimoto [Japon] ; Akio Adachi [Japon]

Source :

RBID : ISTEX:D794C29B8CC13B9086B4C4229682DF03516D51B6

English descriptors

Abstract

The compatibility of rev genes derived from various primate immunodeficiency viruses of all distinct subgroups identified was assessed in three experimental systems: complementation experiments between proviral rev and gag mutants, evaluation of the ability of the rev gene products to activate proviral reporters, and examination of the capacity of various viruses to augment marker gene expression in the infected reporter cell lines. In all systems, human immunodeficiency virus type 1 (HIV-1) rev was not substantially substituted or was extremely poorly substituted by the rev of the other viruses. The rev of simian immunodeficiency virus (SIV) from a mandrill could be exchanged by HIV-1 rev. In contrast, the rev gene products of all viruses efficiently activate HIV-2 and SIV from an African green monkey.

Url:
DOI: 10.1016/0042-6822(91)90421-7


Affiliations:


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Le document en format XML

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<div type="abstract" xml:lang="en">The compatibility of rev genes derived from various primate immunodeficiency viruses of all distinct subgroups identified was assessed in three experimental systems: complementation experiments between proviral rev and gag mutants, evaluation of the ability of the rev gene products to activate proviral reporters, and examination of the capacity of various viruses to augment marker gene expression in the infected reporter cell lines. In all systems, human immunodeficiency virus type 1 (HIV-1) rev was not substantially substituted or was extremely poorly substituted by the rev of the other viruses. The rev of simian immunodeficiency virus (SIV) from a mandrill could be exchanged by HIV-1 rev. In contrast, the rev gene products of all viruses efficiently activate HIV-2 and SIV from an African green monkey.</div>
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